Effect of defibrase on deep vein thrombosis following the surgical treatment of pelvic fracture

Objective: This study is to investigate the effect of defibrase on deep vein thrombosis (DVT) following the surgical treatment for pelvic fracture. Methods: This study included 40 patients who received surgical treatment for pelvic fracture. Blood samples were collected at 24 h before surgery, and 24 h and 72 h after surgery. Plasma levels of endothelin (ET), thromboxane B2 (TXB2), and 6-Keto-PGFla were measured with radioimmunoassay. Plasma D-dimer (D-Di) level was determined with using immune colloidal gold method. Results: For ET and TXB2, in the control group, compared with 24 h before surgery, the plasma ET and TXB2 levels were significantly elevated at 24 h after surgery, which were further increased at 72 h after surgery. In the defibrase group, the plasma ET and TXB2 levels were significantly increased at 24 h after surgery, which were slightly declined 48 h later. Compared with the control groups, the plasma ET and TXB2 levels were significantly declined in the defibrase group at corresponding time points after surgery. For 6-Keto-PGFla and D-Di, in the control group, the plasma 6-Keto-PGFla and D-Di levels were higher at 24 h after surgery than before surgery, which were further elevated 48 h later. In the defibrase group, the plasma 6-Keto-PGFla and D-Di levels were significantly declined at 24 h after surgery, which were further decreased at 72 h after surgery. Conclusion: Defibrase could significantly decline the incidence of DVT following the surgical treatment for pelvic fracture.